Regulation of Human Adipocyte Gene Expression by Thyroid Hormone

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Regulation of gene expression by thyroid hormone.

The thyroid hormones (3,5,3',5'-tetraiodo-L-thyronine [L-T4]' and 3,5,3'triiodo-L-thyronine [L-T3]) have marked effects on the growth, development, and metabolic function of virtually all organ systems and tissues ofhuman beings and other higher organisms (1-3). L-T4 was one of the first hormones to be isolated and its structure determined (4-6). Several decades later L-T3 was identified in the...

متن کامل

Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone.

We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that 3,3',5-tri-iodothyronine (T(3)) inhibits the expression of MUC5AC. The purpose of the present study was to identify mechanisms mediating the effect of T(3). T(3) has been shown to inhibit gene expression ...

متن کامل

In vivo regulation of human skeletal muscle gene expression by thyroid hormone.

Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss. Although the molecular actions of thyroid hormones have been studied thoroughly, their pleiotropic effects are mediated by complex changes in expression of an unknown number of target genes. Here, we...

متن کامل

Estrogen and thyroid hormone interaction on regulation of gene expression.

Estrogen receptor (ER) and thyroid hormone receptors (TRs) are ligand-dependent nuclear transcription factors that can bind to an identical half-site, AGGTCA, of their cognate hormone response elements. By in vitro transfection analysis in CV-1 cells, we show that estrogen induction of chloramphenicol acetyltransferase (CAT) activity in a construct containing a CAT reporter gene under the contr...

متن کامل

Regulation of selenoprotein gene expression and thyroid hormone metabolism.

28 Alessi, D. R., Smythe, C. and Keyse, S. M. (1993) Oncogene 8,2015-2020 29 Stumpo, D. J., Stewart, T. N., Gilman, N. 2. and Blackshear, P. J. (1988) J. Biol. Chem. 263, 16111614 30 Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E. and Woodgett, J. R. (1991) Nature (London) 353,670-674 31 Derjard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R. J. (19...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism

سال: 2002

ISSN: 0021-972X,1945-7197

DOI: 10.1210/jcem.87.2.8200